Hubungan Antara Asupan Purin dan Status Gizi dengan Risiko Penyakit Asam Urat Pria Dewasa di Desa Babakan

Abstract

Asupan purin dan status gizi dapat berhubungan dengan risiko penyakit asam urat. Penelitian ini bertujuan menganalisis hubungan antara asupan purin dan status gizi dengan risiko penyakit asam urat pada pria dewasa di Desa Babakan, Kecamatan Dramaga. Penelitian menggunakan desain cross-sectional dengan teknik stratified random sampling terhadap 84 subjek pria dewasa. Data dikumpulkan melalui wawancara kuesioner, pengukuran antropometri, serta Semi Quantitative Food Frequency Questionnaire (SQ-FFQ) untuk menghitung asupan purin dari makanan yang dikonsumsi, dan dilaksanakan pada Agustus hingga November 2024. Analisis data meliputi analisis univariat, bivariat menggunakan uji Fisher Exact, dan multiple menggunakan regresi logistik biner. Hasil analisis bivariat menunjukkan tidak terdapat hubungan nyata antara usia, pendidikan, besar keluarga, pekerjaan, pendapatan, dan pengeluaran rumah tangga dengan risiko asam urat (p >0,05), sementara terdapat hubungan nyata antara asupan purin (p=0,012) dan status gizi (p=0,041) dengan risiko asam urat. Hasil analisis regresi logistik biner menunjukkan bahwa asupan purin berhubungan nyata dengan risiko asam urat (p=0,012; OR=5,70; 95% CI: 1,47-22,09), demikian pula status gizi (p=0,038; OR=4,29; 95% CI: 1,09-16,98). Penelitian ini menyimpulkan bahwa asupan purin dan status gizi merupakan faktor yang paling dominan berhubungan dengan risiko asam urat pada pria dewasa di Desa Babakan dalam model regresi logistik biner.

Purine intake and nutritional status may be associated with the risk of gout. This study aimed to analyze the association between purine intake and nutritional status and the risk of gout among adult men in Babakan Village, Dramaga District. The study used a cross-sectional design with stratified random sampling of 84 adult male subjects. Data were collected through questionnaire interviews, anthropometric measurements, and the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) to calculate purine intake from consumed foods, and the study was conducted from August to November 2024. Data analysis included univariate and bivariate analyses using the Fisher’s exact test, as well as multiple analysis using binary logistic regression. The results of the bivariate analysis showed no significant association between age, education, family size, occupation, income, and household expenditure with the risk of gout (p >0.05), while there was a significant association between purine intake (p=0.012) and nutritional status (p=0.041) with the risk of gout. The results of the binary logistic regression analysis showed that purine intake was significantly associated with the risk of gout (p=0.012; OR=5.70; 95% CI:1.47–22.09), as was nutritional status/BMI (p=0.038; OR=4.29; 95% CI:1.09–16.98). This study concluded that purine intake and nutritional status were the most dominant factors associated with the risk of gout among adult men in Babakan Village in the binary logistic regression model.