The Consequences of Chronic Unpredictable Stress Exposure to Spatial Memory of Adolescent Mice (Mus musculus albinus).
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Date
2018Author
Christin, Nia
Juliandi, Berry
Boediono, Arief
Sasai, Noriaki
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Adolescence is a sensitive period when neurogenesis rate is increases.
Chronic stress that occurs during adolescence can cause a long-term effects on
adult behavior and morphology of hippocampus. Light-dark transition test showed
that CUS successfully produced depressed adolescent mice. Y-alternation test
revealed that short-term effect of CUS improved spatial memory in mice,
resembled the capability of non-stressed adult while cell counting performed with
HE staining did not showed a significant effect on proliferation, cell maturing, and
cell survival in DG. Complexity of dendrites in DG and pyramidal neurons of
CA1 performed using Golgi-Cox staining. Apical dendrites of DG did not showed
a significant effect of CUS on dendritic complexity of DG. In contrast, both of
apical and basal dendrites of CA1 showed a significant short-term effect of CUS,
seen from the number of intersections. Maximum dendritic span and total
dendritic length did not show a significant differences. It is remarkable that both
short and long-term effect of CUS is changes the complexity of CA1 pyramidal
neuron and transciently increases spatial memory on adolescent mice.
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