| dc.contributor.advisor | Artika, I Made | |
| dc.contributor.advisor | S.Si.,M.Si.,Ph.D, Dodi Safari, | |
| dc.contributor.author | Ardhani, Naura Fianti | |
| dc.date.accessioned | 2026-07-03T02:00:41Z | |
| dc.date.available | 2026-07-03T02:00:41Z | |
| dc.date.issued | 2026 | |
| dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/173960 | |
| dc.description.abstract | Streptococcus pneumoniae merupakan bakteri yang dapat menyebabkan
penyakit seperti otitis media, pneumonia, meningitis, bakteremia, dan sepsis serta
memperoleh sebagian besar patogenisitasnya dari kapsul polisakarida (CPS).
Penelitian ini bertujuan untuk mengkarakterisasi lokus kapsul untuk biosintesis
kapsul polisakarida, resistensi antibiotik, dan variasi genetik dari Streptococcus
pneumoniae serotipe 15B di Indonesia. Diperoleh bahwa serotipe 15B memiliki
prevalensi tinggi di wilayah Lombok, Manado, Sorong, Sumbawa, dan Semarang.
Secara genomik, isolat ini memiliki rata-rata konten GC 39,6% dan ukuran genom
sekitar 2,1 Mbp, dengan dominasi sequence type ST193 dan ST20231 dalam
Global Pneumococcal Sequence Cluster (GPSC) 11. Terdapat sejumlah isolat
yang menunjukkan resistensi terhadap kloramfenikol, tetrasiklin, trimetoprim,
sulfametoksazol, dan ko-trimoksazol. Variasi genetik dari keseluruhan isolat 15B
yang diujikan tergolong rendah, dengan kemiripan mencapai 94%–100% | |
| dc.description.abstract | Streptococcus pneumoniae is a bacterium capable of causing diseases such
as otitis media, pneumonia, meningitis, bacteremia, and sepsis also derives most
of its pathogenicity from its capsular polysaccharide (CPS). This study aims to
characterize the capsule locus, antibiotic resistance, and genetic variation of
Streptococcus pneumoniae serotype 15B in Indonesia. The results showed that
serotype 15B has a high prevalence in the Lombok, Manado, Sorong, Sumbawa,
and Semarang regions. Genomically, these isolates have an average GC content of
39.6% and a genome size of approximately 2.1 Mbp, with a dominance of
sequence types ST193 and ST20231 within the Global Pneumococcal Sequence
Cluster (GPSC) 11. Regarding drug resistance, some of the isolates showed
resistance to chloramphenicol, tetracycline, trimethoprim, sulfamethoxazole, and
co-trimoxazole. The genetic variation among all tested 15B isolates was low, with
similarity ranging from 94% to 100% | |
| dc.description.sponsorship | | |
| dc.language.iso | id | |
| dc.publisher | IPB University | id |
| dc.title | Analisis Komparatif Genomik dan Lokus Gen untuk Biosintesis Polisakarida Kapsul dari Streptococcus pneumoniae Serotipe 15B | id |
| dc.title.alternative | | |
| dc.type | Skripsi | |
| dc.subject.keyword | lokus cps | id |
| dc.subject.keyword | serotipe 15B | id |
| dc.subject.keyword | Streptococcus pneumoniae | id |
| dc.subject.keyword | variasi genetik | id |
| dc.subject.keyword | Whole Genome Sequencing | id |
| dc.subtype | Undergraduate Theses | |
