Diterpenoid Geranylgeraniol Supplementation Suppresses LPS-induced Inflammation in Rat

Abstract

Geranylgeraniol (GGOH) is a natural diterpenoid occurring virtually in all dietary sources which possess the mevalonate pathway, including rice. Rich sources of GGOH include Bixa orellana commonly known for its annatto food colorant which has been used abundantly in many forms of food for daily consumption. One functional aspect of GGOH is its reported anti-inflammatory effect. In this study, we examined the mechanism of GGOH in suppressing inflammation induced by lipopolysaccharide