Keragaman Ruas Ekson 2 dan 3 Gen Penyandi Enzim α-Keto Dehidrogenase E1-α Rantai Asam Amino Bercabang (bckdha) pada sapi madura
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Date
2014Author
Maria, Ria
Farajallah, Achmad
Perwitasari, R.R. Dyah
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Madura cattle is a cattle from the local Indonesian cattle crossbreeding India (Bos indicus) and banteng (Bos javanicus). Enzyme complex branched chain α-keto acid dehydrogenase (BCKDH) located in the inner mitochondrial membrane of eukaryotic cells. BCKDH has a role in changing branched chain amino acids (BCAAs), which is isoleucine, leucine and valine to α-keto form. This enzyme complex consists of three enzyme subunits, one which is E1- α subunit called branched chain α-keto acid dehydrogenase E- α (BCKDHA). Maple syrup urine disease (MSUD) is a genetic disorder caused by one occurrence of mutation in the E1- α subunit. This study aimed to determine the diversity of segment 2 – 3 exon encoding BCKDHA gene in madura cattle. The result revealed that segment of exon 2 – 3 BCKDHA gene in madura cattle J population were found to be identical among them. Furthermore the segment of exon 2 – 3 BCKDHA gene madura cattle J was identical with taurine cattle (Bos taurus).
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