| dc.description.abstract | This study investigates the potential anticancer properties of Cratoxylum
formosum extracts against MDA-MB-231 breast cancer cells. Cratoxylum
formosum extracts were obtained using three different solvents: methanol, ethanol,
and water. Extraction involved maceration and freeze-drying, resulting in extracts
with varied concentrations and colors. MTT assays were employed to assess
cytotoxicity on MDA-MB-231 cells, Vero cells, and EpH4-EV cells. The results
indicated a concentration-dependent increase in MDA-MB-231 cell viability,
notably with the ethanol extract, suggesting potential growth inhibition of cancer
cells. Probit analysis yielded IC50 values of 0.69 µg/mL, 0.72 µg/mL, and 1.73
µg/mL for ethanol, methanol, and water extracts, respectively, highlighting their
potential as potent anticancer agents. While the ethanol extract demonstrates a
smaller IC50, indicating high potency, it also exhibited toxicity to healthy cells.
Conversely, the water extract showed a larger IC50, implying a lower inhibitory
effect on cancer cells with reduced toxicity to healthy cells, suggesting a potential
balance between efficacy and safety. The study suggests that C. formosum extracts
may induce apoptosis in MDA-MB-231 cells, emphasizing their potential as
selective inhibitors of cancer cell growth. This research significantly contributes to
understanding the diverse bioactive components in C. formosum and their potential
applications in developing targeted anticancer therapies. | |
