dc.contributor.advisor | Nurcholis, Waras | |
dc.contributor.advisor | Julistiono,, Heddy | |
dc.contributor.author | Lestari, Sinta Mutiara Dwi | |
dc.date.accessioned | 2024-07-12T06:43:13Z | |
dc.date.available | 2024-07-12T06:43:13Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/153577 | |
dc.description.abstract | Phomopsis sp. diketahui memiliki aktivitas antioksidan yang kuat dalam
melindungi sel dari kerusakan yang disebabkan oleh radikal bebas. Namun, kajian
terkait potensi antioksidan Phomopsis sp. terhadap kadar ureum, kreatinin, dan
MDA (Malondialdehid) ginjal secara in vivo pada tikus Sprague-Dawley betina
yang diinduksi kanker payudara belum dilakukan. Penelitian ini bertujuan
menganalisis potensi antioksidan ekstrak Phomopsis sp. terhadap fungsi ginjal
dengan parameter kadar ureum, kreatinin, dan MDA ginjal secara in vivo pada tikus
Sprague-Dawley betina yang diinduksi kanker payudara. Metode penelitian
meliputi ekstraksi senyawa bioaktif Phomopsis sp., pengkondisian hewan coba,
induksi DMBA pada tikus, pembuatan serum darah untuk uji kreatinin dan urea,
nekropsi dan pengambilan organ ginjal untuk uji MDA ginjal, serta analisis data
menggunakan one-way ANOVA. Hasil penelitian menunjukkan ekstrak Phomopsis
sp. dosis 20 mg/Kg BB merupakan dosis terbaik dengan nilai konsentrasi MDA
(2.974 ± 0.820 nmol/gr), kadar kreatinin (0.417 ± 0.144 mg/dL), serta kadar urea
(18.750 ± 1.250 mg/dL). Ekstrak Phomopsis sp. dosis 20 mg/Kg BB memiliki
potensi antioksidan yang kuat dengan menurunkan nilai MDA, kreatinin, dan urea
secara signifikan. Kadar MDA, kreatinin, dan urea pada ginjal menunjukkan
perubahan yang signifikan (p<0.05) | |
dc.description.abstract | Phomopsis sp. is known to have strong antioxidant activity in protecting cells from damage caused by free radicals. However, studies related to the antioxidant potential of Phomopsis sp. on urea, creatinine, and kidney MDA (Malondialdehyde) levels in vivo in female Sprague-Dawley rats induced with breast cancer have not been conducted. This study aimed to analyze the antioxidant potential of Phomopsis sp. extract on kidney function with parameters of urea, creatinine, and kidney MDA levels in vivo in female Sprague-Dawley rats induced with breast cancer. The research methods include the extraction of bioactive compounds from Phomopsis sp., conditioning of experimental animals, induction of DMBA in rats, preparation of blood serum for creatinine and urea tests, necropsy and kidney organ collection for kidney MDA tests, and data analysis using one-way ANOVA. The results of the study showed that Phomopsis sp. extract at a dose of 20 mg/kg BW was the best dose with MDA concentration values (2.974 ± 0.820 nmol/g), creatinine levels (0.417 ± 0.144 mg/dL), and urea levels (18.750 ± 1.250 mg/dL). Phomopsis sp. extract at a dose of 20 mg/kg BW had strong antioxidant potential by significantly lowering MDA, creatinine, and urea values. Kidney MDA, creatinine, and urea levels showed significant changes (p<0.05). | |
dc.description.sponsorship | | |
dc.language.iso | id | |
dc.publisher | IPB University | id |
dc.title | Analisis Potensi Antioksidan Phomopsis sp. pada Fungsi Ginjal pada Tikus Sprague-Dawley yang diinduksi 7,12-dimetilbenz(a)antrasena. | id |
dc.title.alternative | Analysis of the Antioxidant Potential of Phomopsis sp. on Kidney Function in Sprague-Dawley Rats Induced with 7,12- Dimethylbenz(a)anthracene | |
dc.type | Skripsi | |
dc.subject.keyword | Antioksidan | id |
dc.subject.keyword | in vivo | id |
dc.subject.keyword | kreatinin | id |
dc.subject.keyword | MDA | id |
dc.subject.keyword | Phomopsis sp | id |
dc.subject.keyword | urea | id |