| dc.contributor.advisor | Hanif, Novriyandi | |
| dc.contributor.advisor | Setiawan, Andi | |
| dc.contributor.author | Ningrum, Septiwiana | |
| dc.date.accessioned | 2022-06-08T03:42:24Z | |
| dc.date.available | 2022-06-08T03:42:24Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/111983 | |
| dc.description.abstract | Symploca sp. adalah suatu jenis Cyanobacteria laut yang mempunyai ragam metabolit sekunder dan aktivitas hayati unik yang berpotensi dijadikan sebagai sumber obat baru. Penelitian ini bertujuan mengisolasi senyawa aktif terhadap Artemia salina dari Cyanobacteria laut Symploca sp. asal Ujung Kulon. Pemisahan ekstrak MeOH Symploca sp. menghasilkan fraksi SN-1, SN-2, dan SN-3. Fraksi SN-2 (0,12 g) adalah fraksi paling ampuh (LC50 0,32 μg/mL) terhadap A. salina. Pemurnian SN-2 lebih lanjut menghasilkan tiga subfraksi: SN- 2.1, SN-2.2, dan SN-2.3. Subfraksi SN-2.2 (36,5 mg) menunjukkan toksisitas paling ampuh (LC50 0.10 μg/mL). Berdasarkan analisis HPLC, subfraksi teraktif mempunyai dua komponen senyawa aktif: SN-2.2.3.1.1 dan SN-2.2.3.1.2. | id |
| dc.description.abstract | Symploca sp. is a marine Cyanobacteria possessing diverse and unique secondary metabolites and biological activities which can be used as a source of new drugs. The study aimed to isolate the active molecules against Artemia salina from a marine Cyanobacteria Symploca sp. from Ujung Kulon. Separation of MeOH extract of the Symploca sp. gave SN-1, SN-2, and SN-3 fractions. The SN- 2 (0,12 g) was the most potent fraction (LC50 0,32 μg/mL) against A. salina. Further purification of SN-2 resulted three subfractions: SN-2.1, SN-2.2, and SN- 2.3. The subfraction SN-2.2 (36,5 mg) reveals the most potent toxicity (LC50 0.10 μg/mL). Based on HPLC analysis, the most active subfractions has two components of the active compound: SN-2.2.3.1.1 and SN-2.2.3.1.2. | id |
| dc.language.iso | id | id |
| dc.publisher | IPB University | id |
| dc.title | Isolasi Senyawa Aktif dari Cyanobacteria Laut Symploca sp. Asal Ujung Kulon | id |
| dc.type | Undergraduate Thesis | id |
| dc.subject.keyword | A. salina | id |
| dc.subject.keyword | Cyanobacteria | id |
| dc.subject.keyword | secondary metabolite | id |
| dc.subject.keyword | Symploca sp. | id |
| dc.subject.keyword | toxicity | id |
