| dc.contributor.advisor | Artika, I Made | |
| dc.contributor.advisor | Nurcholis, Waras | |
| dc.contributor.author | Nurjanah, Siti | |
| dc.date.accessioned | 2021-08-16T05:48:31Z | |
| dc.date.available | 2021-08-16T05:48:31Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/108478 | |
| dc.description.abstract | Kanker merupakan salah satu jenis penyakit berbahaya yang mengalami
peningkatan kasus setiap tahunnya. Radikal bebas merupakan penyebab mutasi gen
yang dapat memicu kanker. Kanker akan berkembang tanpa terkendali karena
terjadinya disregulasi siklus sel dan adanya senyawa pemicu proliferasi sel serta
penghambat proses apoptosis. Pengobatan kanker dilakukan dengan memberikan
inhibitor cyclin dependent kinase2 (CDK2) dan cyclooxygenase-2 (COX-2) untuk
menghambat perkembangan kanker, serta inhibitor lipoxygenase (LOX) untuk
menghambat pembentukan radikal bebas. Tanaman temu ireng diketahui memiliki
potensi sebagai antioksidan dan antikanker. Penelitian ini bertujuan mengetahui
interaksi molekuler antara senyawa dominan ekstrak etanol temu ireng dengan
CDK2, COX-2, dan LOX sebagai reseptor. Jenis interaksi ligan dengan reseptor
ditentukan melalui parameter energi afinitas (ΔG), konstanta inhibisi (Ki), jenis
interaksi dan persentase binding site similarity (%BSS). Hasil penelitian
menunjukkan bahwa senyawa uji gajutsulacton A memiliki potensi terbaik dalam
menghambat CDK2. Senyawa uji cucumenol berpotensi sebagai inhibitor COX-2
tetapi tidak terdapat senyawa yang dapat menghambat LOX dengan baik sebagai
antioksidan. | id |
| dc.description.abstract | Cancer is one type of dangerous disease that is increasing every year. Free
radicals are the cause of gene mutations which can lead to cancer. Cancer will
develop uncontrollably due to the dysregulation of the cell cycle and the presence
of compounds which trigger cell proliferation and inhibit the process of apoptosis.
Cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and
cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well
as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. The temu
ireng plant is known to have the potential as an antioxidant and anticancer. This
study aims to determine the molecular interaction between the dominant compound
of temu ireng ethanol extract with CDK2, COX-2, and LOX receptors. The type of
ligand interaction with the receptor was determined through the parameters of
affinity energy (ΔG), inhibition constant (Ki), type of interaction, and percentage
of binding site similarity (%BSS). The results showed that the test compound
gajutsulacton A had the best potential in inhibiting CDK2. The test compound
cucumenol may be a COX-2 inhibitor and there are no compounds that can inhibit
LOX well as an antioxidant. | id |
| dc.language.iso | id | id |
| dc.publisher | IPB University | id |
| dc.title | Penambatan Molekul Senyawa Ekstrak Etanol Rimpang Temu Ireng (Curcuma aeruginosa Roxb.) sebagai Antioksidan dan Antikanker. | id |
| dc.title.alternative | Molecular Docking of Compounds of Ethanol Extract of Temu Ireng Rhizome (Curcuma aeruginosa Roxb.) as Antioxidant and Anticancer. | id |
| dc.type | Undergraduate Thesis | id |
| dc.subject.keyword | Anticancer | id |
| dc.subject.keyword | Antioxidant | id |
| dc.subject.keyword | CDK2 | id |
| dc.subject.keyword | COX-2 | id |
| dc.subject.keyword | LOX | id |
