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Title: | Transformation of Eugenol and SafroleIntoHydroxychavicol Transformasi Eugenol dan Safrol menjadi Hidroksikavikol |
Authors: | Achmadi, Suminar Setiati Arifin, Budi Tang, Dumas Flis |
Keywords: | demethylation demethylenation eugenol hydroxychavicol safrole |
Issue Date: | 2012 |
Publisher: | IPB ( Bogor Agricultural University ) |
Abstract: | Hydroxychavicolis amajorcomponentofbetel leafthat havingantibacterial, anti-inflammatory,antioxidant, anticancer, andantimutagen activities. This studyaimed tosynthesizehydroxychavicol from eugenolandsafrole. Isolation ofeugenolfromclove oilbyalkalineextraction methodgave71% yield, while theisolation ofsafrole from lawang oil byalkalineextraction method, followed by purificationusing preparative TLCgave7% yield. Eugenoldemethylationand safroledemethylenationwithAlCl3reagent weresuccessfullyproducedhydroxychavicol. The yieldswas28% and 24%, respectively Hidroksikavikolmerupakankomponenutamadaunsirih yang memilikiaktivitasantibakteri, antiradang, antioksidan, antikanker, danantimutagen.Penelitianinibertujuanmenyintesissenyawatersebutdarieugenoldan darisafrol.Isolasieugenoldariminyakcengkihdenganmetodeekstraksibasamenghasil kanrendemen 71%, sedangkanisolasisafroldariminyaklawangdenganmetodeekstraksibasadilanjutkand enganpemurnianmenggunakan KLTP mendapatkanrendemen 7%. Proses demetilasiisolateugenoldandemetilenasiisolatsafroldenganpereaksi AlCl3berhasilmendapatkanprodukhidroksikavikol. Rendemen yang diperolehberturut-turut 28% dan 24%. |
URI: | http://repository.ipb.ac.id/handle/123456789/60560 |
Appears in Collections: | UT - Chemistry |
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G12dft.pdf Restricted Access | 1.2 MB | Adobe PDF | View/Open |
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