Transformation of Eugenol and SafroleIntoHydroxychavicol

Abstract

Hydroxychavicolis amajorcomponentofbetel leafthat havingantibacterial, anti-inflammatory,antioxidant, anticancer, andantimutagen activities. This studyaimed tosynthesizehydroxychavicol from eugenolandsafrole. Isolation ofeugenolfromclove oilbyalkalineextraction methodgave71% yield, while theisolation ofsafrole from lawang oil byalkalineextraction method, followed by purificationusing preparative TLCgave7% yield. Eugenoldemethylationand safroledemethylenationwithAlCl3reagent weresuccessfullyproducedhydroxychavicol. The yieldswas28% and 24%, respectively

Hidroksikavikolmerupakankomponenutamadaunsirih yang memilikiaktivitasantibakteri, antiradang, antioksidan, antikanker, danantimutagen.Penelitianinibertujuanmenyintesissenyawatersebutdarieugenoldan darisafrol.Isolasieugenoldariminyakcengkihdenganmetodeekstraksibasamenghasil kanrendemen 71%, sedangkanisolasisafroldariminyaklawangdenganmetodeekstraksibasadilanjutkand enganpemurnianmenggunakan KLTP mendapatkanrendemen 7%. Proses demetilasiisolateugenoldandemetilenasiisolatsafroldenganpereaksi AlCl3berhasilmendapatkanprodukhidroksikavikol. Rendemen yang diperolehberturut-turut 28% dan 24%.