The Effects of Hypothyroidism in the Fertility of Male Rats

Abstract

Thyroid hormones are involved in the development and maintenance of virtually all tissues. The purpose of the study is to understand effects of the neonatal hypothyroidism in the fertility of male rats. Recent studies with juvenile rats indicate that changes in thyroid function early in life have a major impact on the endocrine and/or paracrine factors regulating testicular growth and function. However, one should keep in mind that hypothyroidism is a complex hormonal dysfunction rather than a single hormonal defect. Hypothyroidism has been also shown to reduce the secretion of GnRH (gonadotropins releasing hormone), LH (Luteinizing Hormone), FSH (Follicle Stimulating Hormone), GH (Growth Hormone) and testicular testosterone in rats. Therefore, many of the testicular changes observed in prolonged hypothyroidism could result in some degree of diminished levels of the aforementioned hormones. The transient neonatal hypothyroidism model results in the unnatural testicular development and in sperm production in neonates hence resulting in decreased fertility upon puberty.