Studi histopatologi organ limpa hamster (Mesocricetus auratus) yang Diinfeksi Coxiella burnetii

Abstract

Query fever is a zoonosis caused by Coxiella burnetii (C. burnetii). The aim of this research was to determine the histopathological changes of spleen of hamster (Mesoscricetus auratus) which were infected by C. burnetii using Haematoxylin-Eosin (HE) and Immunohistochemistry (IHC) methods. This research used 6 hamsters which were devided into two passage. The histopathological examination picture with HE staining of first passage in hamsters showed relatively similar results with those the second passage such as red pulp hemorrhage and infiltration of inflammatory cells. Histopathological observation of spleen from first passage hamster by using IHC staining showed the positivity was unclear compared to the second passage hamster.