Hipertrofi Kordis pada Monyet Ekor Panjang (Macaca fasicularis) Pasca Obes Induksi Diet Obesitogenik Diikuti Asupan Nikotin

Abstract

The aim of this study was to examine the evidence of left ventricular hypertrophy of male cynomolgus macaque (Macaca fascicularis) as animal model of human obesity and atherosclerosis. The animals were fed obesitogenic diet for 12 month and treated by per-oral nicotine liquid for 3 month. The objective of this study is exploring the macroscopic aspect of fatty heart enlargement and its compensation. Almost of fifteen samples of hearts showed varies level of fatty deposition and blunted apex. Heart muscle thickening was measured on distal transversal one centimeter’s cutting using caliper with two decimal precision. Relative Wall Thickness (RWT) was measured by calculating Septal Wall Thickness (SWT) that added by Posterior Wall Thickness (PWT) and divided by Left Ventricular Internal Diameter (LVID). All of the heart mostly have concentric type of hypertrophy with elevation of RWT (1.87 ± 1.47 centimeter) compare to the normal one (0,45 centimeter). This RWT has low relations to body weight (r = 0.060) and body mass index (r =0.054). This study refilled that cynomlgous macaque can be developed as animal model of ventricular hypertrophy as a part of alternative solution of ventricular hypertrophy in conjunction with endemic obesity on urban society. This study suggested that the study of nicotine effect on ventricular hypertrophy should be conducted microscopically.