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      KepekaanCandida albicans yangDiisolasidari Beberapa Tempat Pemotongan Unggasdan Pasar Tradisional terhadap Obat Anticendawan Ketokonazol, Itrakonazol dan Griseofulvin

      Susceptibility of Candida albicans which Isolated from Poultry Abattoirs and Traditional Markets to Antifungal Agents of Ketoconazole, Itraconazole and Griseofulvin.

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      Date
      2012
      Author
      Noreva, Patricia
      Pribadi,Eko Sugeng
      Krisnaningsih,Herlien
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      Abstract
      Candidiasis, caused by Candida albicans, is the important mycoses in poultry. In accordance with the development of feed technology, many factors are affecting the health of poultry.Using some antifungals for candidiasis medication are being emerging antifungal-resistant Candida albicans. The study have evaluated sensitivity of C. albicans, which isolated from crops, intestines, and water samples, to the antifungals ketoconazole, itraconazole, and griseofulvin. The result showed that isolated C. albicanswere killed by the antifungal ketoconazole, itraconazole, and griseofulvin except C. albicansthat isolated from intestine sample at TPU Jambu Raya was killed by ketoconazole, and C. albicansthat isolated by intestine and crop samples at RPH Bubulak were killed itraconazole, respectively. There were no significant differences between isolated and reference C. albicans sensitivity (p>0.05) toketoconazole and itraconazole, except to griseofulvin were more sensitive. The ketokonazole was more effective to kill C. albicans than itraconazole and griseofulvin.
       
      Kandidiasis, yang disebabkan oleh Candida albicans, merupakan salah satu penyakit mikosis terpenting dalam peternakan unggas. Seiring dengan berkembangnya teknologi pakan ternak, banyak faktor yang ikut mempengaruhi kesehatan unggas. Penggunaan anticendawan untuk pengobatan kandidiasis akan mempengaruhi resistensi anticendawan terhadap Candida albicans. Penelitian ini bertujuan untuk mengetahui kepekaan C. albicans, yang diisolasi dari tembolok, usus dan air, terhadap anticendawan ketokonazol, itrakonazol, dan griseofulvin. Penelitian ini juga menunjukkan bahwa C. albicansmasih peka terhadap pemberian anticendawan ketokonazol, itrakonazol, dan griseofulvin kecuali isolat C. albicans yang berasal dari potongan usus TPU Jambu Raya terhadap ketokonazol serta isolat C. albicans yang berasal dari potongan usus dan tembolok RPH Bubulak terhadap itrakonazol. Tidak terdapat perbedaan nyata (p>0,05) dalam kepekaan anticendawan antara C. albicans yang diisolasi dari contoh dengan referensi, kecuali griseofulvin yang lebih peka. Ketokonazol lebih efektif membunuh isolat C. albicans dibandingkan itrakonazol dan griseofulvin.
       
      URI
      http://repository.ipb.ac.id/handle/123456789/54933
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      • UT - Animal Disease and Veterinary Health [877]

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