Studi Pengembangan Skala Laboratorium Kadar Na, K, Ca, Mg Pada Produk Cairan Konsentrat untuk Aplikasi Hemodialisis

Abstract

Hemodialisis merupakan terapi pengganti ginjal yang membutuhkan cairan konsentrat dengan mutu terkontrol karena berperan dalam menjaga keseimbangan elektrolit selama proses dialisis. Cairan konsentrat hemodialisis harus memiliki karakteristik fisikokimia yang sesuai serta kadar elektrolit utama yang memenuhi spesifikasi agar aman dan layak digunakan. Penelitian ini bertujuan mengembangkan cairan konsentrat hemodialisis skala laboratorium berdasarkan formulasi acuan. Evaluasi mutu meliputi warna, kejernihan, homogenitas, endapan, pH, turbiditas, serta kadar elektrolit utama Na?, K?, Ca²?, dan Mg²? menggunakan Spektrofotometri Serapan Atom. Hasil menunjukkan produk tidak berwarna, jernih, homogen, dan tidak terdapat endapan. Nilai pH sebesar 2,28, turbiditas 1,0914 NTU, serta kadar Na? 108,8 mmol/L, K? 2,17 mmol/L, Ca²? 1,93 mmol/L, dan Mg²? 1,03 mmol/L. Berdasarkan hasil evaluasi, cairan konsentrat hemodialisis skala laboratorium yang dikembangkan menggunakan formulasi acuan menunjukkan mutu fisikokimia dan kadar elektrolit utama yang sesuai dengan standar acuan.

Hemodialysis is a renal replacement therapy that requires a concentrate solution with controlled quality. Hemodialysis concentrate solution must have appropriate physicochemical characteristics and major electrolyte levels. This study aimed to develop a laboratory-scale hemodialysis concentrate solution based on a reference formulation. Quality evaluation included color, clarity, homogeneity, precipitate formation, pH, turbidity, and the levels of major electrolytes, namely Na?, K?, Ca²?, and Mg²?, using Atomic Absorption Spectrophotometry. The results showed that the product was colorless, clear, homogeneous, and free from precipitate. The pH value was 2.28, turbidity was 1.0914 NTU, and the electrolyte levels were Na? 108.8 mmol/L, K? 2.17 mmol/L, Ca²? 2.02 mmol/L, and Mg²? 1.03 mmol/L. Based on the evaluation results, the laboratory-scale hemodialysis concentrate developed using the reference formulation demonstrated physicochemical quality and main electrolyte levels that complied with the reference standards.