EFEKTIVITAS KOMBINASI INFUSA RIMPANG KUNYIT (Curcuma longa) DENGAN HERBA PEGAGAN (Centella asiatica) SEBAGAI ANALGESIK DAN ANTIINFLAMASI

Abstract

NSAID merupakan salah satu obat yang sering digunakan dalam mengobati rasa nyeri. Meskipun memiliki berbagai manfaat, penggunaan jangka panjang dapat menimbulkan efek samping. Oleh karena itu, diperlukan alternatif terapi yang lebih aman dengan pemanfaatan bahan herbal. Rimpang kunyit (Curcuma longa) dan herba pegagan (Centella asiatica) diketahui memiliki potensi sebagai agen analgesik dan antiinflamasi karena sejumlah kandungan aktif yang berperan dalam menghambat proses peradangan. Penelitian ini bertujuan untuk menguji efektivitas kombinasi kedua tanaman tersebut dalam bentuk infusa pada 5 kelompok mencit (Mus musculus) komposisi 4 ekor/kelompok dengan konsentrasi berbeda (0%, 1%, 5%, 10%, 15%). Pemberian dilakukan melalui air minum menggunakan metode pre-treatment selama 14 hari. Selanjutnya, dilakukan pengujian efek analgesik menggunakan metode hot water immersion test pada jam ke 0,4,8 dan 12 serta efek antiinflamasi melalui induksi edema karagenan 1% pada jam ke-0, 3 6 dan 9. Nilai AUC dan daya inhibisi inflamasi dihitung serta aspek panca radang dinilai. Hasil penelitian menunjukkan bahwa infusa memberikan efek analgesik dengan onset beragam. Pada uji antiinflamasi, infus konsentrasi 10% menjadi konsentrasi terbaik dengan nilai AUC terendah dan daya inhibisi inflamasi tertinggi.

NSAIDs are among the most frequently used medications for pain management. Despite their therapeutic benefits, long-term use of NSAIDs can lead to adverse side effects. Consequently, there is a need for safer alternative therapies, such as the utilization of herbal ingredients. Turmeric rhizome (Curcuma longa) and gotu kola herb (Centella asiatica) are known to possess potential as analgesic and anti-inflammatory agents due to their active compounds that play a role in inhibiting the inflammatory process. This study aims to evaluate the effectiveness of the combination of these two plants in the form of an infusion across 5 groups of mice (Mus musculus), with 4 mice per group, at varying concentrations (0%, 1%, 5%, 10%, and 15%). The administration was carried out via drinking water using a 14-day pre-treatment method. Subsequently, the analgesic effect was evaluated using the hot water immersion test at hours 0, 4, 8, and 12, while the anti inflammatory effect was assessed through 1% carrageenan-induced edema at hours 0, 3, 6, and 9. The Area Under the Curve (AUC) value and the percentage of inflammation inhibition were calculated, and the five cardinal signs of inflammation (panca radang) were assessed. The results indicated that the infusion provided analgesic effects with varying onset times. In the anti-inflammatory test, the 10% infusion concentration proved to be the most effective concentration, yielding the lowest AUC value and the highest inflammation inhibition capacity.