dc.contributor.advisor | Purwono, Rini Madyastuti | |
dc.contributor.advisor | Laila, Sri Rahmatul | |
dc.contributor.author | Hidayat, Muhammad Ihsan | |
dc.date.accessioned | 2024-07-15T06:11:05Z | |
dc.date.available | 2024-07-15T06:11:05Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/153653 | |
dc.description.abstract | Interleukin 6 dapat memberikan efek sebagai proinflamasi melalui aktivasi
trans-signaling sehingga memperparah anjing yang terkena inflammatory bowel
disease. Penghambatan interleukin 6 pada sisi aktifnya berpotensi menjadi
alternatif pengobatan kasus IBD. Daun pepaya diketahui mengandung senyawa
aktif yang memiliki aktivitas sebagai imunomodulator. Penelitian ini bertujuan
memprediksi potensi senyawa aktif daun pepaya sebagai inhibitor interleukin 6
menggunakan metode in silico dengan azathioprine sebagai ligan pembanding.
Sebanyak lima senyawa yaitu myricetin, cycloartenol, quercetin, kaempferol, dan
chlorogenic acid melalui analisis bioavailabilitas dan toksisitas sebelum dilakukan
penambatan molekuler. Kelima ligan uji memiliki nilai ?G lebih negatif
dibandingkan ligan pembanding dan berikatan pada sisi aktif. Senyawa myricetin
menunjukkan hasil penambatan terbaik dengan energi afinitas 6,6 kkal/mol dan
pembentukan ikatan hidrogen pada semua sisi aktif, sehingga myricetin berpotensi
sebagai inhibitor interleukin 6. | |
dc.description.abstract | Interleukin 6 can be proinflammatory through the activation of transsignaling, thus aggravating dogs affected by inflammatory bowel
disease. Inhibition of interleukin 6 on the active site has the potential to be an
alternative treatment for IBD cases. Papaya leaves are known contain active
compounds that have activity as immunomodulators. This study aims to predict
the potential of active compounds in papaya leaves as inhibitors of interleukin 6
using the in silico method with azathioprine as comparator ligand. A total of five
compounds, namely myricetin, cycloartenol, quercetin, kaempferol, dan
chlorogenic acid were used through bioavailability and toxicity analysis before
molecular docking. All of ligand has a more negative ?G value compared to
reference ligand and binds to the active site. Myricetin shows the best docking
results with an affinity energy of 6.6 kcal/mol and formation of hydrogen bond on
all active sites, so that myricetin has potential as an inhibitor of interleukin 6. | |
dc.description.sponsorship | - | |
dc.language.iso | id | |
dc.publisher | IPB University | id |
dc.title | Studi In Silico Potensi Daun Pepaya (Carica papaa L.) Sebagai Imunomodulator Melalui Inhibisi Interleukin 6 | id |
dc.title.alternative | Study In Silico Potential of Papaya Leaves (Carica papaya L.) as an Immunomodulator Through Interleukin 6 Inhibition | |
dc.type | Skripsi | |
dc.subject.keyword | In silico | id |
dc.subject.keyword | daun pepaya | id |
dc.subject.keyword | imunomodulator | id |
dc.subject.keyword | inflammatory bowel disease | id |
dc.subject.keyword | interleukin 6 | id |