| dc.contributor.advisor | Sari, Yessie Widya | |
| dc.contributor.advisor | Wahyuni, Wulan Tri | |
| dc.contributor.author | Pembajeng, Thomasin Amadea Putri | |
| dc.date.accessioned | 2023-08-29T08:00:28Z | |
| dc.date.available | 2023-08-29T08:00:28Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/124440 | |
| dc.description | Tugas Akhir ini mohon untuk tidak segera ditampilkan di Repository IPB. Surat permohonan dan Ketua Departemen akan menyusul. | id |
| dc.description.abstract | Penelitian ini bertujuan menganalisis pengaruh variasi variabel formulasi terhadap sifat fisikokimia mikrosfer berbahan dasar biopolimer. Metode yang digunakan adalah meta-analisis dengan pendekatan regresi linear sederhana. Variabel formulasi mikrosfer seperti kecepatan emulsifikasi, rasio obat-polimer, dan konsentrasi penaut silang berperan sebagai variabel bebas. Sifat fisikokimia mikrosfer seperti ukuran partikel, efisiensi enkapsulasi (%EE), dan laju pelepasan obat (%Drugrelease) berperan sebagai variabel terikat. Penarikan kesimpulan dilakukan berdasarkan nilai p-value, koefisien determinasi (R2), dan gradien. Morfologi mikrosfer diamati menggunakan citra hasil uji SEM. Interaksi obat polimer juga dianalisis melalui hasil uji DSC untuk analisis termal dan uji FTIR untuk analisis gugus fungsi. | id |
| dc.description.abstract | This study aims to analyze the effect of various formulation variables on the physicochemical properties of biopolymer microspheres. The method used is meta-analysis with a simple linear regression approach. The microsphere formulation variables such as stirring speed, drug-polymer ratio, and crosslinker concentration act as independent variables. The physicochemical properties of microspheres such as particle size, encapsulation efficiency (%EE), and drug release rate (%Drugrelease) act as dependent variables. Conclusions are drawn based on the p-value, the coefficient of determination (R2), and the gradient. The morphology of the microspheres was observed using SEM results. Drug-polymer interactions were also analyzed by DSC for thermal analysis and FTIR for functional group analysis. | id |
| dc.language.iso | id | id |
| dc.publisher | IPB University | id |
| dc.title | Analisis Pengaruh Variabel Formulasi Terhadap Sifat Fisikokimia Mikrosfer Biopolimer | id |
| dc.title.alternative | Analysis of the Effect of Formulation Variables on the Physicochemical Properties of Biopolymer Microspheres | id |
| dc.type | Undergraduate Thesis | id |
| dc.subject.keyword | biopolymer | id |
| dc.subject.keyword | meta-analysis, | id |
| dc.subject.keyword | microspheres | id |
| dc.subject.keyword | physicochemical properties | id |
