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      Pengaruh Infusa Ginseng Jawa (Talinum paniculatum) terhadap Ketahanan Otot Mencit (Mus musculus) dalam Pengujian Renang

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      Date
      2023-08-11
      Author
      Leksono, Christina Clarice
      Manalu, Wasmen
      Purwono, Rini Madyastuti
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      Abstract
      Peningkatan perilaku sedenter dalam masyarakat menyebabkan penurunan ketahanan otot. Ginseng jawa (Talinum paniculatum) berpotensi meningkatkan ketahanan otot karena memiliki kandungan ginsenosida. Penelitian ini bertujuan menguji efektivitas dan dosis efektif infusa ginseng jawa untuk meningkatkan ketahanan otot dengan menggunakan mencit sebagai hewan model. Sebanyak 25 ekor mencit jantan dibagi menjadi 5 kelompok, yakni 1) kelompok mencit yang diberi 53 μL akuades tanpa pemberian infusa akar ginseng jawa sebagai kelompok kontrol negatif; 2) kelompok mencit yang diberi infusa akar ginseng jawa dengan dosis 0,05 g/kg BB; 3) kelompok mencit yang diberi infusa akar ginseng jawa dengan dosis 0,1 g/kg BB; 4) kelompok mencit yang diberi infusa akar ginseng jawa dengan dosis 0,3 g/kg BB; dan 5) kontrol positif yang diberi taurin dengan dosis 1,3 mg/kg BB. Pengujian dilakukan dengan uji ketahanan berenang sebanyak 3 kali pengulangan dengan interval 6 jam setelah 7 hari perlakuan. Parameter yang diamati mencakup durasi renang, suhu tubuh, frekuensi napas, dan frekuensi denyut jantung. Analisis data menggunakan analisis ragam (ANOVA) satu arah kemudian dilanjutkan dengan uji Tukey. Hasil penelitian menunjukkan bahwa pemberian infusa ginseng jawa paling efektif meningkatkan durasi renang pada dosis 0,3 g/kg BB dengan perbandingan lurus antara durasi renang dan dosis pemberian infusa ginseng jawa.
       
      Increases in sedentary behavior decreases muscle endurance. Java ginseng (Talinum paniculatum) may improve muscle endurance with its ginsenoside content. This study aims to test the effectiveness and effective dosage of java ginseng infusion in increasing muscle endurance in mice. A total of 25 male mice were divided into 5 groups of treatments i.e., 1) experimental mice administered with 53 μL distilled water without java ginseng infusion as a negative control, 2) experimental mice administered with java ginseng infusion at a dose of 0,05 g/kg BW; 3) experimental mice administered with java ginseng infusion at a dose of 0,1g/kg BW; 4) experimental mice administered with java ginseng infusion at a dose of 0,3 g/kg BW, and 5) experimental mice administered with taurine at a dose of 1,3 mg/kg BWas a positive control. The experiment was conducted using the forced swimming test, 3 repetitions with a 6-hour interval after 7 days of treatment. Parameters observed were swim duration, body temperature, respiratory rate, and heart rate. Data analysis was conducted using one-way analysis of variance followed by Tukey’s post-hoc test. Results showed that treatment using java ginseng infusion most effectively increased swim duration with the 0,3 g/kg BW dose, positively correlated with dosage.
       
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      http://repository.ipb.ac.id/handle/123456789/123841
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      • UT - Anatomy, Phisiology and Pharmacology [1047]

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      Indonesia DSpace Group 
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