Profil Klinis Induk Sapi Frisien Holstein Bunting Sesudah Pemberian Vaksin Avian Influenza H5N1
Date
2021Author
Priyatmo, Rega
Esfandiari, Anita
Setiadi, Mohamad Agus
Metadata
Show full item recordAbstract
Penelitian ini bertujuan untuk mengamati profil klinis induk sapi perah
Friesian Holstein (FH) bunting yang divaksin dengan vaksin Avian Influenza
H5N1 melalui pengamatan suhu tubuh, frekuensi respirasi dan pulsus. Sebanyak
sembilan ekor induk sapi Friesian Holstein (FH) bunting trimester akhir dibagi
ke dalam tiga kelompok, yaitu kelompok kontrol (3 ekor, tidak diberi
imunomodulator, antigen AI H5N1 dan vaksin AI H5N1 inaktif), kelompok A
(3 ekor, tidak diberi imunomodulator, diberi antigen AI H5N1, dan divaksin AI
H5N1 inaktif), dan kelompok B (3 ekor, diberi imunomodulator, antigen anti
AI H5N1, dan vaksin AI H5N1 inaktif). Induk sapi diberikan imunomodulator
dengan rute oral selama tiga hari berturut-turut sebelum vaksinasi dengan dosis
0,1 ml/kgBB. Imunomodulator yang digunakan berjenis polipeptida
ribonukleotida. Setelah itu induk sapi kelompok A dan B disuntik dengan
antigen (Ag) H5N1 in-aktif tanpa adjuvan secara intra-vena selama tiga hari
berturut-turut dengan dosis 104 HAU/ekor. Selanjutnya induk sapi A dan B
divaksin menggunakan vaksin AI H5N1 in-aktif komersial sebanyak 5 dosis
unggas/ekor secara subkutan. Vaksin diberikan sebanyak tiga kali, masingmasing dengan interval waktu antar vaksinasi dua minggu. Parameter
pemeriksaan fisik yang diamati meliputi suhu tubuh, frekuensi pulsus dan
frekuensi respirasi. Pemeriksaan fisik dilakukan sebelum vaksinasi pertama, 3
hari berturut-turut setelah vaksinasi pertama, kedua dan ketiga (hasil angkaangka). Hasil pemeriksaan suhu tubuh, frekuensi respirasi dan pulsus kelompok
A dan B pada vaksinasi I, II, dan III masih didalam kisaran normal. Pemberian
vaksin H5N1 inaktif pada induk sapi bunting Friesian Holstein tidak
berpengaruh negatif terhadap status kesehatan hewan tersebut. This study aims to observe the clinical profile of Friesian Holstein (FH)
pregnant dairy cows vaccinated with Avian Influenza H5N1 vaccine through
observations of body temperature, respiration frequency and pulsus. A total of
nine final trimester pregnant Friesian Holstein (FH) cows were divided into
three groups, namely the control group (3 cows, not given immunomodulators,
AI H5N1 antigen and inactive H5N1 AI vaccine), group A (3 cows, not given
immunomodulators, were given AI H5N1 antigens, and inactivated AI H5N1
vaccines), and group B (3 animals, were given immunomodulators, H5N1 anti
AI antigens, and inactivated AI H5N1 vaccines). Cows were given
immunomodulators by oral route for three consecutive days before vaccination
at a dose of 0.1 ml/kgBB. The immunomodulator used is a ribonucleotide
polypeptide. After that, cows in groups A and B were injected with in-active
H5N1 antigen (Ag) without adjuvant intravenously for three consecutive days
at a dose of 104 HAU/head. Furthermore, cows A and B were vaccinated using
the commercial in-active H5N1 AI vaccine as many as 5 doses of poultry/head
subcutaneously. The vaccine is given three times, each with a time interval
between vaccinations of two weeks. Physical examination parameters observed
included body temperature, pulse rate and respiration rate. Physical
examination was carried out before the first vaccination, 3 consecutive days
after the first, second and third vaccinations (results figures). The results of
examinations of body temperature, respiration frequency and pulses of groups
A and B in vaccinations I, II, and III were still in the normal range. The
conclusion of this study was that the administration of inactivated H5N1 vaccine
to pregnant Friesian Holstein cows did not have a negative effect on the health
status of these animals.