Efektivitas Pemberian Ekstrak Kunyit (Curcuma domestica) dan Simvastatin terhadap Kadar Kolesterol Darah dan Bobot Badan pada Kelinci (Orytolagus cuniculus) Hiperkolesterolemia

Abstract

This study was conducted to observe cholesterol levels of rabbits fed a diet high cholesterol (hypercholesterolemia) and treatment with simvastatin and turmeric extract. Nine male rabbits weighing 1.5-2.1 kg with aged 1 year were divided into 3 groups; control group (untreated), hypercholesterolemia group fed a diet high of cholesterol then given simvastatin, hypercholesterolemia group fed a diet high cholesterol then given extracts of turmeric. Hypercholesterolemia group derived from the diet in the form of palm oil which is heated for 10 minutes also egg yolks for 3 weeks and then given simvastatin at a dose of 1.2mg / kg of body weight and turmeric extracts with 1.66ml dose / kg of body weight in the next week. Measurement of blood cholesterol levels using the kit NESCO AMS Chol4 / 092 711. The data obtained were analyzed with Microsoft Excel and and Analysis of Variance (ANOVA) with a confidence level of 95% and followed by Duncan's test. This study shows that dietary coconut oil at a dose of 4% of the total feed of 100 gram and egg yolk with 1 egg doses can increase blood cholesterol levels at week-2 gived. Treatment with simvastatin and turmeric extract can lower blood cholesterol levels in the first week of treatment.