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http://repository.ipb.ac.id/handle/123456789/122305
Title: | Gambaran Hematologi dan Aktivitas Enzimatis Hati Tikus Hiperkolesterolemia yang Diberikan "Emping-Dadih" |
Other Titles: | Hematology and Liver Enzymatic Activity of Hypercholesterolemia Rats Given “Emping-Dadih” |
Authors: | Laila, Sri Rahmatul Gunanti, Gunanti Reza, Sasqia Mallikah Aulia |
Issue Date: | 20-Jul-2023 |
Publisher: | IPB University |
Abstract: | Hypercholesterolemia is a condition of high cholesterol in the blood. It can
lead to death due to occurring cardiovascular disease. Prevention and treatment of
hypercholesterolemia using traditional food black glutinous rice and fermented
buffalo milk (“emping-dadih or ED”) may affect blood profiles and liver
enzymatic activity. This study aimed to analyze various parameters of red blood
cells, white blood cells, and thrombocytes, also liver enzymatic activities of rat
giving high-cholesterol and ED. This study was conducted using 25 male
Sprague-Dawley rats divided into five treatment groups, namely negative control
(A), positive control/hypercholesterolemia (B), ED prevention (C), ED treatment
(D), and atorvastatin treatment (E). Hematology and liver enzymatic comparison
for all groups were analyzed by descriptive and ANOVA. The results showed that
ED increased the number of erythrocytes, decreased the number of platelets and
leukocytes as indicators decreased of inflammation. “Emping-dadih” also
significantly reduced SGPT/ALT and SGOT/AST activities than in
hypercholesterolemia conditions. This study showed that “emping-dadih” was
able to improve the hematological profile and enzymatic activity of the liver in
hypercholesterolemia rats. Hiperkolesterolemia adalah suatu kondisi kolesterol yang tinggi di dalam darah. Hal ini dapat menyebabkan kematian karena memicu terjadinya penyakit kardiovaskular. Pencegahan dan pengobatan hiperkolesterolemia menggunakan pangan tradisional beras ketan hitam dan dadih (“emping-dadih” atau ED) dapat memengaruhi profil darah dan aktivitas enzimatis hati. Penelitian ini bertujuan menganalisis berbagai parameter sel darah merah, sel darah putih, dan trombosit, serta aktivitas enzimatis hati tikus yang diberikan kolesterol dan ED. Penelitian ini dilakukan dengan menggunakan 25 ekor tikus jantan Sprague-Dawley yang dibagi menjadi lima kelompok perlakuan, yaitu kontrol negatif (A), kontrol positif/hiperkolesterolemia (B), pencegahan ED (C), pengobatan ED (D), dan pengobatan atorvastatin (E). Perbandingan hematologi dan enzimatis hati untuk semua kelompok dianalisis secara deskriptif dan ANOVA. Hasil penelitian menunjukkan bahwa ED meningkatkan jumlah eritrosit, menurunkan jumlah trombosit dan leukosit sebagai indikator penurunan inflamasi. “Emping-dadih” juga secara signifikan mengurangi aktivitas SGPT/ALT dan SGOT/AST dibandingkan dengan kondisi hiperkolesterolemia. Penelitian ini menunjukkan bahwa “emping-dadih” mampu memperbaiki profil hematologi dan aktivitas enzimatis hati pada tikus hiperkolesterolemia. |
URI: | http://repository.ipb.ac.id/handle/123456789/122305 |
Appears in Collections: | UT - Anatomy, Phisiology and Pharmacology |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01 Watermark (Cover) - SKRIPSI - (B04190076) SASQIA MALLIKAH AULIA REZA.pdf Restricted Access | Cover | 353.09 kB | Adobe PDF | View/Open |
02 Watermark (Fullteks) - SKRIPSI - (B04190076) SASQIA MALLIKAH AULIA REZA.pdf Restricted Access | Fulltext | 607.66 kB | Adobe PDF | View/Open |
03 Watermark (Lampiran) - SKRIPSI - (B04190076) SASQIA MALLIKAH AULIA REZA.pdf Restricted Access | Lampiran | 310.49 kB | Adobe PDF | View/Open |
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