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Title: | Efektivitas Terapi Stem Cell pada Infark Miokardium Ditinjau dari Nilai Ureum, Kreatinin dan Histopatologi Ginjal. |
Other Titles: | Effectiveness of Stem Cell Therapy in Myocardial Infarction a Review of Values Creatinine, Ureum and Kidney Histopathology |
Authors: | Gunanti, Gunanti Noviana, Deni Harlina, Eva Rahmi, Nur |
Issue Date: | May-2023 |
Publisher: | IPB University |
Abstract: | Infark miokardium merupakan suatu kondisi terbentuknya nekrosis
miokardium ditandai dengan penurunan cardiac output yang memicu terjadinya
acute kidney injury. Terapi stem cell adalah metode yang dapat memperbaiki infark
miokardium. Penelitian ini bertujuan untuk mempelajari efektivias terapi stem cell
placenta tunggal maupun kombinasi kardiomiosit pada babi yang mengalami infark
miokardium ditinjau dari nilai ureum, kreatinin dan histopatologi organ ginjal.
Sebanyak 9 ekor babi di bagi menjadi tiga kelompok, yaitu tanpa terapi (K1), terapi
stem cell placenta tunggal (K2), dan terapi kombinasi kokultur kardiomiosit (K3).
Seluruh babi dilakukan ligasi arteri circumflexa coronary untuk mensimulasikan
iskemia jantung dan setelah 1 jam ligasi dilakukan pemberian terapi. Hasil
penelitian menunjukkan penurunan nilai ureum dan kreatinin pada K2 dan K3.
Hasil histopatologi ditemukan kongesti atrofi glomerulus, dan nekrosis tubulus.
Berdasarkan uji analysis of variance (ANOVA) menunjukkan ada perbedaaan yang
nyata (p < 0,05). Disimpulkan bahwa pemberian terapi stem cell placenta maupun
yang dikombinasi dengan kokultur kardiomiosit dapat menurunkan nilai ureum,
kreatinin, dan memperbaiki jaringan ginjal secara histopatologi.
Kata kunci: infark miokardium, ginjal, histopatologi, ureum, kreatinin, stem cell ABSTRACT Myocardial infarction is a condition where myocardial necrosis develops which is characterized by a decrease in cardiac output that triggers acute kidney injury. Stem cell therapy is a method that can repair myocardial infarction. This study aims to study the effectiveness of placental stem cell therapy alone or in combination with cardiomyocytes in pigs with myocardial infarction in terms of urea, creatinine and histopathological values of the kidneys. A total of 9 pigs were divided into three groups, namely without therapy (K1), single placenta stem cell therapy (K2), and combined therapy with cardiomyocyte coculture (K3). All pigs underwent coronary circumflex artery ligation to simulate cardiac ischemia and after 1 hour of ligation, therapy was given. The results showed an decreased in urea and creatinine values in the K2 and K3 groups. Histopathological results were congestion, glomerular atrophy, and tubular necrosis. Based on the analysis of variance (ANOVA) test, it showed that there was a significant difference (p<0.05). It was concluded that administration of placental stem cell therapy or in combination with cardiomyocyte coculture can reduce urea, creatinine,and improve kidney tissue histopathologically. Keywords: myocardial infarction, kidney, histopathology, urea, creatinine, stem cell |
URI: | http://repository.ipb.ac.id/handle/123456789/117276 |
Appears in Collections: | MT - Veterinary Science |
Files in This Item:
File | Description | Size | Format | |
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Cover_B3501202038_NUR RAHMI.-2.pdf | Cover | 352.16 kB | Adobe PDF | View/Open |
B3501202038_NUR RAHMI.pdf Restricted Access | Fulltext | 872.54 kB | Adobe PDF | View/Open |
LAMPIRAN.pdf Restricted Access | Lampiran | 188.61 kB | Adobe PDF | View/Open |
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