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dc.contributor.authorJuniastuti
dc.contributor.authorPutra, Victor Eka Nugraha
dc.contributor.authorAmin, Mochamad
dc.contributor.authorMertaniasih, Ni Made
dc.contributor.authorLusida, Maria Inge
dc.date.accessioned2011-03-23T05:54:18Z
dc.date.available2011-03-23T05:54:18Z
dc.date.issued2009
dc.identifier.issn1978-3477
dc.identifier.urihttp://repository.ipb.ac.id/handle/123456789/42953
dc.description.abstractThe genotypes (A-H) and subtypes (adw2, adw4, adrq-, adrq+, ayw1-4, ayr) of HBV show distinct geographical distributions, which have been associated with anthropological history. The novel finding of the HBV subgenotypes C6 and D6 from Papuans formed a specific cluster distinct from the previous HBV subgenotypes C1-C5 and D1-D5. In this study we determined the most recent genotype-subtype patterns of the HBV from non-Papuan blood donors who live in Jayapura and their phylogenetic relatedness, especially with the Papuan clusters. Fifteen HBsAg-positive serums were obtained from non-Papuan blood donors including from people in Java (46.7%), Maluku (26.7%), Sulawesi (20%) and East Nusa Tenggara (6.7%). S gene of all HBV serum isolates were partially sequenced and analyzed. Most HBV isolates (53.3%) were classified as genotype B, followed by genotype C (26.7%) and D (20.0%). The subtype adw2 (33.3%) was predominant, followed by adrq+ (26.7%) and ayw1/ayw2 (20.0%). All HBV isolates with subtype adw2 and ayw1 belonged to genotype B, while adrq+ belonged to genotype C and ayw2 belonged to genotype D. The most predominant HBV genotype-subtype (B/adw2) was consistent with the ethnic background (mostly from Java people). Nevertheless, based on the phylogenetic relatedness, many non Papuan isolates (40%) were classified into HBV/C6 and HBV/D6 of the Papuan clusters. Other isolates were classified into HBV/C1, HBV/B3 and HBV/B7. In conclusion, many HBV isolates from non-Papuans in Jayapura belonged to the Papuan clusters, but others had different genotype-subtype patterns with frequencies dependent on ethnicity.en
dc.publisherIPB (Bogor Agricultural University)
dc.relation.ispartofseriesVol.3;No.2
dc.titleThe Relatedness between Hepatitis B Virus from Non-Papuan Blood Donors in Jayapura and the Papuan Clustersen
dc.title.alternativeMicrobiology Indonesia Vol.3 No.2 Tahun 2009en


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