Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae isolated from Female Commercial Sex Workers in Jakarta

Abstract

The control sexually transmitted diseases STDs of infection has become more urgent since it has been documented that untreated STDs infection facilitates HIV transmission. One of the most frequent cause of STDs reported is Neisseria gonorrhoeae. Problem of gonorrheal infection is complicated by the occurrence of resistant strains all over the world. In this study, gonococcal isolation have been attempted from 165 endocervical swabs from Female Commercial Sex Workers FCSW5 in Kramat Tunggak and Kedoya Jakarta. Of 114 Kramat Tunggak's samples examined, 6153.5% were positive for gonococcal cultures, whereas 13 25.5% from 51 Kedoya's sample were positive. The penicillinase-producing N. gonorrhoeae of gonococcal isolates from Kramat Tunggak and Kedoya were 73.8% and 92.3%, respectively. The result of the Minimun Inhibitory Concentration tests for 6 antimicrohials thiamphenicol, kanamycin, spectinomycin, ciprolloxacin, cefuroxime, and ceftriaxonc shows that 1.6% isolates were resistant and 34.4% isolates were intermediate to the kanamycin, and 1.6% isolates were intermediate to the thiamphenicol, and all isolates were sensitive to the spectinomycin, ciprofloxacin, cefuroxime, and ceftriaxone. Antibiotic with best activity in vitro was tluoroquinolone ciprofloxacin. Whereas antimicrobial activity of the cephalo-sporins ceftriaxone, and cefuroxime were better than spectinomycin, thiamphenicol, and kanamycin.