Antioxidant activity of ginger (Zingiber officinale) Oleorsin on the profile of superoxide dismutase (SOD) in the Kidney of rats under stress conditions

Abstract

Stress condition has been reporfed to decrease intrasellular antioxidant-superoxide dismutase (SOD) in the liver and kidney of rats. This study was conducted to evaluate the antioxidant activities of ginger deoresin on the profile of supsroxide dismutase (SOD) in the kidney of rats under stress condition. The stress condition was achieved by five days of fasting together with swimming for 5 midday. Ginger deoresin was orally administrated ic a dose of 60 mg/KgB:'/lday for seven d9ys. Drinking water was provided ad libitum to all groups. The tmdment of ginger oleoresin significantly decreased malondialdehyd5 (h4DA) lltvels end increased SOD activity, as well as immunohistochemicall, increased the content of copper, zinc-SOD (Cu,Z.?-SOD) in the kidney tissues compared to that of untreated group. The entioxidant content in ginger oleoresin such as shogaol, zingeron, and uinqerol, etc. were shownto have activities in the kidney tissues of rats under stress condition that is increasing the profile of SOD. Ginger oleoresin treatment in combination both before and after stress geve the best results.