| dc.description.abstract | According to in vivo studies on secondary metabolites of albutra (akar kuning plant, Arcangelisia flava (L) Merr), saponins extract without alkaloids showed a hepatoprotector activity. The best extracting solvent was mixture of methanol :dichloromethane (2:1), followed by refluxing in a mixture of ethyl acetate:chloroform (1:1) medium, and precipitating in acetone. Yield of the glycoside was 7.4%. The glycoside fraction was able to inhibit 58% of the increasing aspartate transaminase activities and 52% of the increasing alanine transaminase activities in liver destruction of Sprague Dawley rat, caused by paracetamol | id |
