| dc.description.abstract | Septic shock induce severe vasoplegia, reduced vascular tone, and impaired tissue perfusion. The timing of norepinephrine administration as the first-line vasopressor remains debated. This study aimed to evaluate the effect of early norepinephrine administration on clinical parameters in septic shock patients. A randomized clinical trial was conducted involving 44 patients with septic shock in the RSUD Cibinong. The treatment group (n=22) received norepinephrine at 0.05 mcg/kg/min along with maintenance fluids, whereas the control group (n=22) received norepinephrine only if the target mean arterial pressure (MAP) ≥ 65 mmHg was not achieved after fluid resuscitation. Hypotension duration was recorded within the first 24 hours. Sequential Organ Failure Assessment (SOFA) score, lactate levels, central venous oxygen saturation (ScvO₂), thoracic fluid content (TFC), stroke volume variation (SVV), and cardiac contractility index (CCI) were measured at 0, 1, 3, and 24 hours post-admission. The treatment group showed a significantly shorter duration of hypotension compared to the control group (6.36 ± 2.46 vs 13.31 ± 4.41 minutes; p<0.001). Additionally, the treatment group demonstrated significantly better SOFA scores, lactate levels, ScvO₂, TFC, SVV, and CCI at 1, 3, and 24 hours post-admission compared to the control group. Sepsis management with early norepinephrine administration results in significant clinical improvement in patients with septic shock. | id |
