| dc.description.abstract | Leaf extract of Tephrosia vogelii has been extensively tested and proven its
effectiveness as a pesticide against some species of insect pests. Botanical insecticides that can
be used as integrated pest management in the field are not only effective against the target pest
but also meet the safety requirements of non-target organisms. The objective of this study was
to test the acute toxicity and gross pathology effect of T. vogelii leaf extract on white rats in the
laboratory. Four doses (25, 50, 100, and 200 ppm of body weight) of plant extracts were tested
according to rat body weight. Five white rats were used in each treatment. The extract was given
in a single dose using a blunt tip syringe. Observations were carried out five times after
application and were also carried out every day for fourteen days. The variable observed were
mortality of rats, consumption of un-hulled rice, and symptoms of poisoning in the internal
organs of rats. The mortality data were analyzed to determine the LD50 of the leaf extract. The
result indicates that LD50 of T. vogelii extract is 92.90 ppm of body weight and very toxic to
treated rats. The body weights of the rats decreased on the first day after treatment. Extract of
leaf T. vogelii reduced the consumption of rats to un-hulled rice at the three highest doses. The
highest dose (200 ppm) of the extract caused a hundred percent of mortality, congestion in the
liver and lungs, and inflammation in the intestines and stomach. | id |
