Potensi Antihiperkolesterolemia Ekstrak Seduhan Teh Herbal Lempuyang Gajah (Zingiber zerumbet L.)

Abstract

The objective of this research was to study the effectivity of herbal tea compositions of lempuyang gajah as antihypercholesterolemic agent. Extracts were tested in Sprague-Dawley male rats. Forty six rats were divided into four experimental groups as follow: normal, hyperlipidemic, herbal tea extract 1, and herbal tea extract 2. Rats were made hiperlipidemic by oral administration of propil tiouracil (0.5 mg/Kg BW) and high cholesterol feeding (1.5 % cholesterol). Total blood cholesterol concentrations were measured by cholesterol oxidase enzymatic methods of ‘CHOD-PAP’ using spectrophotometer at wavelenght 500 nm. Results showed that cholesterol diet increased blood cholesterol concentration by 76.11 % (p=0.004). Following free cholesterol diet (washed out period), blood cholesterol concentration was decreased by 43.82 % (p=0.101). Similarly, extract 1 reduced cholesterol concentration by 43.20 % (p=0.005). Antihyperlipidemic potency of extract 2 is higher than extract 1 as shown by significant reduction of cholesterol by 51.70 % (p=0.000).