Model minimal kinetika glukosa dan insulin untuk mendeteksi diabetes tipe 2

Abstract

Insulin sensitivity and pancreatic responsivity are two main factors controlling glucose tolerance. This research has proposed minimal model modified by rule introducing a mathematical model for describing the insulin infusion rate. The modified model was used to study three sets of published data including healthy human and type 2 diabetes with different types of insulin infusion rates. From the model parameter, it is possible to extract four indices: (1) SG, parameter discribes glucose effectiveness, which is the effect of glucose to normalize the glucose concentration at basal insulin, (2) SI, the tissue insulin sensitivity index, (3) ϕ1, first phase pancreatic responsitivity, and (4) ϕ2, second phase pancreatic responsitivity. These four characteristic parameters have been shown to represent an integrated metabolic potrait of a single individual.