Efek Antihiperglikemik Ekstrak Etanol Daun Mimba (Azadirachta Indica J) Pada Tikus Diabetes yang Diinduksi Aloksan dan Pengembangannya Menjadi Sediaan Tablet Menggunakan Metode Granulasi Basah (Antihyperglycaemic Effect Of Azadirachta Indica J Extract On Alloxsan – Induced Diabetic Rat And Tablet Formulation Used Wet Granulation)
Date
2009Author
Priosoeryanto, Bambang Pontjo
Prasetyo, Bayu Febram
Wientarsih, Ietje
Madyastuti, Rini
Metadata
Show full item recordAbstract
This study was aimed to determine antihyperglycaemic effect of Azadirachta indica J extract on alloxan-induced diabetic rat, active compound indentification, and tablet formulation This study used 18 mice Spraque Dawley strains are divided into 6 groups. The results of this study indicate that extracts dose given orally 30, 60 and 90mg / kg body weight showed a decrease of blood glucose levels of diabetes mice alloxsan significant (P <0.05) by 7%, 8%, and 14.8% after giving repeatedly extracts on the tenth day compared with the sixth day. Indentification of flavonoid compound showed antocianidin which have flavylium (2-fenil-benzopyrylium) ion on the first fraction and the second fraction showed antocianidin : ion flavylium (2-fenil-benzopyrylium) , 7- hidroksi flavylium 4'-hidroksi flavylium, and 3,4,7'-trihidroksi flavylium Mimba extract could be made on tablet formulation used PVP K-30 on wet granulation.
Collections
- Proceedings [2790]