Echocardiography Evaluation in Piglet (Sus scrota) during Recruitment Maneuver on Pediatric Acute Lung Injury Model

Abstract

Acute lung injury (ALI) is the acute onset of bilateral infiltrate on chest radiograph without evidence of left atrial hypertension and with a partial pressure of oxygen (Pa02)/ fraction of inspired oxygen (FiOz) ratio of less than 300 [1]. ALI characterized by destruction of alveolarcapillary integrity with manifestations of increased capillary permeability, non-hydrostatic pulmonary edema. alveolar collapse. decreased lung compliance, and ventilation - perfusion mismatch as the main cause of hypoxemia [2]. An ALI patient usually manages by mechanical ventilation but improper use can worsen occurred lung injury, especially in children. Recent can be handled by recruitment maneuvers. The effectiveness of the mechanical ventilation is measured by cardiac output (CO) of the left heart ventricle for supplying oxygen to the body [3]. Therefore, evaluation of echocardiography is necessary. This study use piglets (Sus sero/a) as an animal model due to its similar anatomical and physiological structure to human. ...