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DC Field | Value | Language |
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dc.contributor.author | I. Batubara | |
dc.contributor.author | S. Kotsuka | |
dc.contributor.author | K. Yamauchi | |
dc.contributor.author | H. Kuspradini | |
dc.contributor.author | T. Mitsunaga | |
dc.contributor.author | L.K. Darusman | |
dc.date.accessioned | 2015-10-15T02:46:49Z | |
dc.date.available | 2015-10-15T02:46:49Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1819-3455 | - |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/76512 | |
dc.description.abstract | In this study 28 Indonesian medicinal plants species has been screened as potential Tumor Necrosis Factor (TNF)-a inhibitor. Plant materials were extracted with methanol. The activity test was performed on human monocyte-derived THP-1 (ATCC No. TIB 202) which was stimulated by Lipopolysaccharide (LPS). The TNF-a production and cell viability were determined by commercial ELISA kit and WST-1, respectively. All extracts were determined for their phenolic, flavonoid and tannin contents by spectrophotometry and chromatography methods. From 40 plant materials, 5 plant materials had cell viability lower than 70% at 10 ppm concentration and about 8 plant materials had good cell viability higher than 90% at 10 ppm concentration. Among 8 plant materials extract which had good cell viability, only Avicennia sp. stem and Goniothalamus macrophyllus leaf methanol extracts had high TNF-a inhibitory activity. The total phenolic, flavonoid and tannin contents were varied depending on the sample. No correlation was found between TNF-a inhibitory activity with the total phenolic content, flavonoid content and tannin content. In conclusion, among Indonesian medicinal plants, the highest potential as TNF-a inhibitors were Avicennia sp. stem and G. macrophyllus leaves. | en |
dc.language.iso | en | |
dc.publisher | Academic Journals Inc | |
dc.relation.ispartofseries | 6 (6): 406-415, 2012; | - |
dc.subject.ddc | Indonesian medicinal plants | en |
dc.subject.ddc | TNF-a inhibitor | en |
dc.subject.ddc | inflammation | en |
dc.subject.ddc | phenolic | en |
dc.subject.ddc | flavonoid | en |
dc.subject.ddc | tannin | en |
dc.title | TNF-a Production Inhibitory Activity, Phenolic, Flavonoid and Tannin Contents of Selected Indonesian Medicinal Plants | en |
dc.type | Article | en |
Appears in Collections: | Faculty of Mathematics and Natural Sciences |
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File | Size | Format | |
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TNF-(alfa) production inhibitory activity, phenolic, flavonoid and tannin contents.pdf | 584.89 kB | Adobe PDF | View/Open |
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