Flavonoid from Intsia palembanica as Skin Whitening Agent

Please use this identifier to cite or link to this item: http://repository.ipb.ac.id/handle/123456789/76459

Title:	Flavonoid from Intsia palembanica as Skin Whitening Agent
Authors:	I. Batubara L.K. Darusman T. Mitsunaga H. Aoki M. Rahminiwati
Issue Date:	2011
Publisher:	Asian Network for Scientific Information
Series/Report no.:	11 (8): 475-480, 2011;
Abstract:	This study aims to obtain active compounds from Intsia palembanica with skin whitening activity. I. palembanica methanol extracts were separated using chromatography techniques and yielded 3 flavanols. Isolated compounds along with 6 other flavonoid compounds were analyzed for tyrosinase inhibitory activity and inhibition of melanin cell growth in Bl 6 cell. The results showed that (-)-robidanol is the most potent tyrosinase inhibitor (IC50 monophenolase 8.7 μM; diphenolase 26.6 μM) and inhibit melanin synthesis 46.2% compared to control (at 100 μM). In conclusion, (-)-robidanol is the best compound as a whitening agent.
URI:	http://repository.ipb.ac.id/handle/123456789/76459
ISSN:	1727-3048
Appears in Collections:	Faculty of Mathematics and Natural Sciences

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