Inhibisi Ekstrak Air Kumis kucing dan Tempuyung terhadap Aktivitas ACE (Angiotensin Converting Enzyme) secara In Vitro

Abstract

Angiotensin converting enzyme (ACE) plays an important role in the regulation of blood pressure. ACE works by converting inactive decapeptide angiotensin I to angiotensin II which can increase blood pressure (hypertension). Kumis kucing and tempuyung plants were macerate using water and the yield were 11% and 9%, respectively. Total flavonoid content of kumis kucing and tempuyung’s extracts were 2.33×10-1% and 1.07×10-1%, respectively. The ACE inhibitory activity were tested and gave 69% for single extract of 50 ppm kumis kucing, 40% for single extract of 50 ppm tempuyung, and 88% for captopryl (control) at 25 ppm concentration. The inhibition of a single extract kumis kucing at a concentration of 50 ppm can be a natural ACE inhibitors and may is potential as an antihypertensive.