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Title: | Inhibisi Ekstrak Pegagan (Centella asiatica L.) dan Tempuyung (Sonchus arvensis L.) terhadap Aktivitas ACE (Angiotensin Converting Enzyme) |
Other Titles: | Inhibition of Pegagan (Centellaasiatica) and Tempuyung (Sonchusarvensis) Extracts towards Angiotensin Converting Enzyme (ACE) Activity |
Authors: | Pradono, Dyah Iswantini Rahminiwati, Min Budiman, Lilla |
Issue Date: | 2014 |
Publisher: | Bogor Agricultural University (IPB) |
Abstract: | Pegagan dan tempuyung merupakan tanaman obat yang berpotensi sebagai antihipertensi. Ekstrak tanaman ini diteliti daya inhibisinya terhadap aktivitas enzim pengubah angiotensin I (ACE) secara in vitro. Penelitian dilakukan pada kondisi optimum menggunakan ekstrak tunggal dengan konsentrasi 50, 100, dan 150 ppm serta ekstrak gabungan dengan komposisi tertentu. Hasilnya dibandingkan dengan kaptopril sebagai kontrol positif. Uji inhibisi ACE dengan ekstrak tunggal pegagan dan tempuyung 50 ppm menghasilkan daya inhibisi paling tinggi yaitu 54% dan 31%. Esktrak gabungan pegagan tempuyung menghasilkan daya inhibisi yang lebih rendah dibandingkan ekstrak tunggal pegagan, yaitu 45% berbanding 54%. Kaptopril memiliki daya inhibisi yang paling tinggi dibandingkan ekstrak tunggal maupun gabungan, yaitu 88%. Kata Kunci: Inhibisi ACE, kaptopril, pegagan, tempuyung Pegagan and tempuyung are medicinal plants potential as antihypertension. Extracts of these plants were investigated towards angiotensin I converting enzyme (ACE) inhibition activity in vitro. The study was conducted at the optimum condition by using 50,100 and 150 ppm of single extract concentration, and combined extracts with specific compositions. The results were compared with captopril as positive control. Inhibition test of ACE with single extracts showed that 50 ppm pegagan and tempuyung have the highest inhibition of 54% and 31%. The combined extracts of pegagan and tempuyung showed lower inhibition than single pegagan extract, i.e. 45% versus 54%. Captopril still indicated the highest inhibition (88%) as compared to single or combined extracts. Key words: ACE inhibition, captopril, pegagan, tempuyung |
URI: | http://repository.ipb.ac.id/handle/123456789/72689 |
Appears in Collections: | UT - Chemistry |
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G14lbu.pdf Restricted Access | Full Text | 475.74 kB | Adobe PDF | View/Open |
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