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DC Field | Value | Language |
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dc.contributor.author | W., Winarsih, | |
dc.contributor.author | Wientarsih, I. | |
dc.contributor.author | Handharyani, E. | |
dc.contributor.author | Estuningsih, S. | |
dc.contributor.author | Widhyari, SD. | |
dc.date.accessioned | 2014-12-16T02:25:17Z | |
dc.date.available | 2014-12-16T02:25:17Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/71450 | |
dc.description.abstract | Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak rimpang kunyit dalam prows persembuhan luka pada mencit yang diinduksi diabetes dengan streptozotocin. Ekstrak rimpang kunyit yaitu fraksi etil asetat dan hexan dibuat sediaan farmasi salep. Enam puluh ekor mencit diinduksi sterptozotocin dengan dosis 40mg/kg secara intraperitonial (ip). Mencit dibagi men jadi 4 kelompok yaitu kontrol positif (obat komersial neomycin sulfat 5%), kelompok diabetes (diinduksi diabetes, tidak diobati); kelompok III (salep fraksi etil asetat) dan kelompok IV (salep fraksi hexan). Salep diberikan secara topikal 2 kali/hari. Tiga mencit dari setiap kelompok dinekropsi pada hari ke 2, 4, 7, 14 dan 21 hari pasca perlukaan untuk pemeriksaan patologi anatomi dan histopatologi. Secara patologi anatomi kelompok yang diberi salep fraksi etil asetat dan hexan menunjukkan persembuhan yang lebih baik dari kelompok diabetes. Secara mikroskopis kelompok yang diberi salep fraksi etil asetat dan hexan rnenunjukkan pembentukan neovaskularisasi dan reepitelisasi yang lebih cepat dibanding kelompok diabetes. Jurnlah sel neutrofil pada kelompok diabetes lebih banyak dibandingkan kelompok yang diberi salep fraksi etil asetat dan hexan,hal ini menunjukkan kemampuan anti inflamasi pada fraksi etil asetat dan hexan. Berdasarkan perubahan makroskopik dan mikroskopik, sediaan salep fraksi etil asetat dan hexan dapat memperbaiki proses persembuhan luka pada mencit diabetes. | en |
dc.description.abstract | The aim of this research was to evaluate the effectiveness of turmeric extract on the wound healing process in streptozotocin-induced diabetic mice. Turmeric extract (ethyl acetate and hexane fractions) were studied for their wound-healing properties in the formulation of ointment. Sixty mice were i.p injected with 40mg/bw of sterptozotocin and divided into 4 groups; positive control (treated with commercial gel which contained neomycin sulfat 5%): diabetic group (without treatment); group III (treated with ethyl acetate fraction ointment), group IV (treated with hexane fraction ointment). The ointment of ethyl acetate and hexane fractions were given topically twice a day. Three mice from each groups were necropsied at 2nd 4th 7`n 14th and 21st days post incisition (pi) for gross pathology and histopathological evaluation of the injured skin. Gross examination revealed that the ethyl acetate and hexane fractions ointment groups showed better result on wound-healing process compared to the diabetic group. Microscopically, the ethyl acetate and hexane fractions ointment group showed faster neovascularization and reepithelialization compared to the diabetic group. The amount of neutrophyl infiltration revealed that the diabetic group showed more cells than ethyl acetate and hexane fractions groups, which indicated anti inflammatory activities of ethyl acetate and hexane fractions. Based on the macroscopic and microscopic observation, the ointment of ethyl acetate and hexane fractions have got properties which promotes wound healing in diabetic mice. | en |
dc.language.iso | id | |
dc.title | Kajian aktivitas ekstrak rimpang kunyit (curcuma tonga) dalam proses persembuhan luka pada mencit sebagai model penderita diabetes | en |
dc.title.alternative | Prosiding Seminar Hasil-Hasil Penelitian IPB 2009 | en |
dc.type | Article | en |
dc.subject.keyword | Penyembuhan luka | en |
dc.subject.keyword | diabetes | en |
dc.subject.keyword | ekstraks rimpang kunyit | en |
dc.subject.keyword | salep | en |
dc.subject.keyword | patologi | en |
Appears in Collections: | Research Proceeding |
Files in This Item:
File | Description | Size | Format | |
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BIDANG KESEHATAN ok.doc | Abstract | 678.5 kB | Microsoft Word | View/Open |
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