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Title: | Keragaman Ruas Ekson 2 dan 3 Gen Penyandi Enzim α-Keto Dehidrogenase E1-α Rantai Asam Amino Bercabang (bckdha) pada sapi madura |
Authors: | Farajallah, Achmad Perwitasari, R.R. Dyah Maria, Ria |
Issue Date: | 2014 |
Abstract: | Madura cattle is a cattle from the local Indonesian cattle crossbreeding India (Bos indicus) and banteng (Bos javanicus). Enzyme complex branched chain α-keto acid dehydrogenase (BCKDH) located in the inner mitochondrial membrane of eukaryotic cells. BCKDH has a role in changing branched chain amino acids (BCAAs), which is isoleucine, leucine and valine to α-keto form. This enzyme complex consists of three enzyme subunits, one which is E1- α subunit called branched chain α-keto acid dehydrogenase E- α (BCKDHA). Maple syrup urine disease (MSUD) is a genetic disorder caused by one occurrence of mutation in the E1- α subunit. This study aimed to determine the diversity of segment 2 – 3 exon encoding BCKDHA gene in madura cattle. The result revealed that segment of exon 2 – 3 BCKDHA gene in madura cattle J population were found to be identical among them. Furthermore the segment of exon 2 – 3 BCKDHA gene madura cattle J was identical with taurine cattle (Bos taurus). |
URI: | http://repository.ipb.ac.id/handle/123456789/70491 |
Appears in Collections: | UT - Biology |
Files in This Item:
File | Description | Size | Format | |
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G14rma.pdf Restricted Access | full text | 988.04 kB | Adobe PDF | View/Open |
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