Pancreatic Beta Cells Evaluation After Treated By Phaleria macrocarpa (Mahkota Dewa0 Fruit Extract in Diabetic Monkey

Abstract

Phaleria macrocarpa, is a medicinal plants originated from Papua. Empirically, it is capable to control \arious health problems including diabetes mellitus. There is growing evidence that excess generation of highly reactive free radicals largely due to oxidative stress (hyperglycemia) causing increase blood level. This further exacerbates the development and progression of diabetes and its complications. Based on previous studies, Phaleria macrocarpa contained antioxidant of phenolic glycoside (Oshimi, et al., 2008) and lignans pinoresinol, lariciresinol, and matairesinol (Saufi et aI, 2008). The aim of this study was to evaluate the numhcr of heta cell pancreas and to detect antigenantihody reaction of ~ cells after treated Phaleria macrocarpa fruit extract in diabetic monkey (DM) induccd with streptozotocin (STZ).