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http://repository.ipb.ac.id/handle/123456789/61792
Title: | Behavior of Chitosan-Alginate Gel Coated Ketoprofen Dissolution Based on Tween 80 Concentration Perilaku Disolusi Mikrokapsul Ketoprofen Tersalut Gel Kitosan-Alginat Berdasarkan Ragam Konsentrasi Tween 80 |
Authors: | Sugita, Purwantiningsih Kemala, Tetty Arianto, Bayu Dwi |
Keywords: | Bogor Agricultural University (IPB) |
Issue Date: | 2010 |
Abstract: | Chitosan ability to form gel has been extensively studied and modified; natural hydrocoloid addition is just an example. Chitosan-alginate gel has a promising potential to be applied as a good coating material in drugs delivery system. In this study, chitosanalginate gel coated ketoprofen microcapsules were made using spray drying method. Tween 80 solution concentration used in the process was varied (1, 2, and 3% (v/v)). The resulting microcapsules particle sizes were ranging from 150 nm to 6 μm. The dissolution test results showed that the Tween 80 solution concentrations were affecting ketoprofen releasing rate for the microcapsule. Maximum ketoprofen release rates either in acidic or basic medium were observed at 2% Tween 80 concentration. The maximum released ketoprofen amounts in acidic and basic medium were 35.19 and 287.92 ppm, respectively. The releasing mechanism was determined by evaluating the releasing kinetic models. The ketoprofen releasing kinetic model, both in acidic and basic medium, was following the Hixson-Crowell kinetic model. |
URI: | http://repository.ipb.ac.id/handle/123456789/61792 |
Appears in Collections: | UT - Chemistry |
Files in This Item:
File | Description | Size | Format | |
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G10bda1.pdf Restricted Access | Fulltext | 3.72 MB | Adobe PDF | View/Open |
Abstract.pdf Restricted Access | Abstract | 278.6 kB | Adobe PDF | View/Open |
BAB I Pendahuluan.pdf Restricted Access | BAB I | 291.73 kB | Adobe PDF | View/Open |
BAB II Tinjauan Pustaka.pdf Restricted Access | BAB II | 334.21 kB | Adobe PDF | View/Open |
BAB III Bahan dan Lingkup Kerja.pdf Restricted Access | BAB III | 299.69 kB | Adobe PDF | View/Open |
BAB IV Hasil dan Pembahasan.pdf Restricted Access | BAB IV | 3.58 MB | Adobe PDF | View/Open |
BAB V Kesimpulan dan Saran.pdf Restricted Access | BAB V | 280.97 kB | Adobe PDF | View/Open |
Cover.pdf Restricted Access | Cover | 280.27 kB | Adobe PDF | View/Open |
Daftar Pustaka.pdf Restricted Access | Daftar Pustaka | 286.06 kB | Adobe PDF | View/Open |
Lampiran.pdf Restricted Access | Lampiran | 321.37 kB | Adobe PDF | View/Open |
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