Uji aktivitas hepatoprotektor ekstrak air pegagan (Centella asiatica) terhadap tikus putih jantan yang diinduksi parasetamol

Abstract

This study was undertaken to investigate activity of Centella asiatica extract against paracetamol induced liver damage in male Wistar albino rats. Rats were divided into five groups namely control (aquadest), herb extract with four formulations which were F 6, F 10, F 12, and F 16. Rats were administered paracetamol at dose 1000 mg/kg bw (p.o) as toxic dose for inducing hepatotoxicity. Herb extract in each formula was given at dose 1500 mg/kg bw (p.o) one hour after paracetamol administration. The treatment was given for eight days and blood was collected three times (before treatment, after paracetamol treatment, and last treatment) from tail artery and analysed for serum glutamate pyruvate transminase (SGPT). The hepatoxicity produced by acute paracetamol administration was found to be inhibited by Centella asiatica at group F 16 with evidence of decreased level of serum glutamate pyruvate transminase (SGPT) consentration. The hepatoprotective activity Centella asiatica was also supported by histopathological studies of hepatocytes