Neuroprotective Effect of Temulawak (Curcuma xanthorhiza) on Braine Nerve Cell Damage Induced by Lipopolysaccharide (LPS)

Abstract

Alzheimer's is a disease characterized by memory loss. This occurred as a result of permanent brain damage. Antiinflammatory and antihypertensive drugs that act by inhibiting an enzyme acetylcholinesterase can inhibit the occurrence of more severe brain damage. Temulawak has been reported to have anti-inflammatory effects. Therefore, temulawak may have ability to work as a protector of the brain nerves. This research was aimed to study the potency of temulawak as neuroprotector through the study of inhibitory activity against acetyl cholinesterase and protective effect against further brain cell damage due to LPS in vitro. The obtained results show that temulawak can inhibit the activity of the enzyme acetyl cholinesterase and prevent further brain damage due to LPS. This result indicates that the temulawak has potential as neuroprotector.