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DC Field | Value | Language |
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dc.contributor.advisor | Arifin, Budi | |
dc.contributor.advisor | Sugita, Purwantiningsih | |
dc.contributor.author | Utami, Dwi | |
dc.date.accessioned | 2012-11-28T04:16:14Z | |
dc.date.available | 2012-11-28T04:16:14Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://repository.ipb.ac.id/handle/123456789/58624 | |
dc.description.abstract | Flavone is a class of flavonoid, widely distributed in vascular plants. Flavones containing hydroxyl groups at 5 and 7 position are quite important regarding their biological activities and their abiquity in nature. Flavone having hydroxyl groups only at position 5 and 7 or 5,7-dihydroxyflavone is known as chrysin. In this study, crude chrysin had been successfully synthesized in 3 steps from phloroglucinol as starting material. Phloroglucinol was acetylated with acetonitrile and HCl gas, resulting phloroacetophenone amount to 74%. Phloroacetophenone benzoylation with 4.5 equivalents of benzoyl chloride produced tribenzoyl phloroacetophenone in 103–107% of yield and the subsequent Baker-Venkataraman rearrangement of the ester by using KOH in dried pyridine produced crude chrysin, with conversion percentage of 71.62%. All synthetic products had been characterized by melting point and spectroscopically. | en |
dc.subject | Bogor Agricultural University (IPB) | en |
dc.title | Sintesis Krisin dari Floroglusinol | en |
Appears in Collections: | UT - Chemistry |
Files in This Item:
File | Size | Format | |
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G12dut.pdf Restricted Access | 2.03 MB | Adobe PDF | View/Open |
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