Clinical pathology and pathomorphological studies of dogs with jaundice related to plasma-lymphocytic interstitial nephritis

Abstract

Dogs are considered maintenance and incidental hosts for some infectious diseases, and also are potential source of infection. This is a oclinical pathology and pathomorphological studies of four dogs with jaundice and kidney disorder. The clinical pathology examinations demonstrated that those dogs showed elevation values of mean cell haernoglobin concentration (MCHC), granulocytes, aspartate aminohnsferase (AST), alanin transarninase (ALT), total bilirubin, blood urea nitrogen (BUN) and c~atinine. All dogs were treated with antibiotic and syrnphtomatic therapy, unfortunately it was not help. Histopatological evaluation found that, the kidneys of all dogs were characterized by inflammatory reactions. The inflammatory cells consisted of plasma-lymphmytic oelIs, and were frequently form muffihcal composition in the interstitial spaces and accompanied by formation of interstitial fibrosis, degeneration and necroses of tubular epithelial cells. In addition, histopathological changes on liver were characterized by congestion and hemorrhages which considered relate 'to the AST and ALT values. These findings suggested that clinical pathology examinations were strongly associated with the occurrence of plasma-mphocytic interstitial nephritis in dogs.