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http://repository.ipb.ac.id/handle/123456789/43522
Title: | Potensi Senyawa 2-Hidroksinikotinil Serin Metil Oktanoil Ester Dan 2-Hidroksinikotinil Oktilamida Sebagai Antikanker |
Authors: | Hariyanti |
Keywords: | Pharamocology Abnormal cells |
Issue Date: | 2010 |
Publisher: | IPB (Bogor Agricultural University) |
Abstract: | The novel compounds of 2-hydroxynicotinyl serine methyl octanoyl ester (NSMOE) and 2-hydroxynicotinyl octylamide (NOA) were synthesized by modifying of the UK-3A compound known biologically active to inhibit bacterial and cancer cells growth. Based on e-docking value of -11.12 kcal/mol (log P 1.49) for NSMOE and e-docking -10.46 kcal/mol (log P 2.50) for NOA, synthesis of these two compounds were carried out in two-step reaction for the first compound and one step reaction for the second compound. The synthesis of NSMOE started by amidation reaction between L-serine methyl ester and 2-hydroxynicotinic acid yielded 87.8% of 2-hydroxynicotinyl serine methyl ester, which was further esterified with octanoic acid yielded 74.5% of NSMOE. Overall yield of NSMOE was 65.4%. NOA was synthesized by amidation reaction between 2-hydroxynocotinic acid and octylamin yielded 76.1% of the product. The compound were confirmed with Fourier transformed infrared spectrometry, liquid chromatography mass spectroscopy, and nuclear magnetic resonance spectrometry. In vitro test to murine leukemia P-388 cells and breast cancer T47D demonstrated that the inhibition to growth of cancer cells with IC50 for NSMOE ,and NOA were 10.0; 3.19, and 32.0; 4.67 µg/mL, respectively. The IC50 values indicated that the synthesis products were sufficiently potential to be anticancer for murine leukemia P-388 cells and breast cancer T47D. |
URI: | http://repository.ipb.ac.id/handle/123456789/43522 |
Appears in Collections: | MT - Mathematics and Natural Science |
Files in This Item:
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2010har2.pdf Restricted Access | Full text | 1.37 MB | Adobe PDF | View/Open |
Abstract - 2010har2.ps Restricted Access | PostScript | 14.3 MB | Postscript | View/Open |
Abstract - 2010har2.pdf Restricted Access | Abstract | 312.41 kB | Adobe PDF | View/Open |
BAB I Pendahuluan -2010ha.pdf Restricted Access | BAB I | 308.26 kB | Adobe PDF | View/Open |
BAB II. Tinjauan Pustaka - 2010har2.pdf Restricted Access | BAB II | 381.03 kB | Adobe PDF | View/Open |
BAB III. Metode - 2010har2-3.pdf Restricted Access | BAB III | 299.9 kB | Adobe PDF | View/Open |
BAB IV. Hasil&Pembahasan - 2010har2.pdf Restricted Access | BAB IV | 560.83 kB | Adobe PDF | View/Open |
Cover - 2010har2.pdf Restricted Access | Cover | 281.3 kB | Adobe PDF | View/Open |
DAftar Pustaka -2010har2.pdf Restricted Access | Daftar Pustaka | 288.43 kB | Adobe PDF | View/Open |
Kesimpulan - 2010har2.pdf Restricted Access | BAB V | 279.74 kB | Adobe PDF | View/Open |
LAmpiran - 2010har2.pdf Restricted Access | Lampiran | 903.79 kB | Adobe PDF | View/Open |
Prakata - 2010har2.pdf Restricted Access | Prakata | 277.13 kB | Adobe PDF | View/Open |
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