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Title: | The Immunohistochemical Profile of Superoxide Dismutase (SOD) in the Liver Tissue of Hypercholesterolemic Rats |
Other Titles: | HAYATI Journal of Biosciences Vol. 13 No.3 Tahun 2006 |
Authors: | Wresdiyati, Tutiek Astawan, Made Hastanti, Lusia |
Issue Date: | 2006 |
Publisher: | IPB (Bogor Agricultural University) |
Series/Report no.: | Vol 13;No 3 |
Abstract: | This study was conducted to observe intracellular antioxidant cooper,zinc-superoxide dismutase (Cu,Zn-SOD) in liver tissue of rats under hypercholesterolemic condition by using immunohistochemical technique. A total of twenty male Wistar rats were used for this study. Those rats were divided into two groups; (i) control group and (ii) hypercholesterolemic group, which were fed died containing 1% cholesterol for eight weeks. Rat livers were taken at the end of treatment, and processed by using paraffin embedding standard method. The tissues were stained immunohistochemically to Cu,Zn-SOD. Observation of Cu,Zn-SOD content in the tissue was performed qualitatively in the cytoplasm and quantitatively in the nucleus of hepatocytes based on colour intensity of enzyme reaction product. The profile of antioxidant-Cu,Zn-SOD decreased (P < 0.05) in the hypercholesterolemic group compared to the control group. |
URI: | http://repository.ipb.ac.id/handle/123456789/43323 |
ISSN: | 0854-8587 |
Appears in Collections: | Hayati Journal of Biosciences |
Files in This Item:
File | Description | Size | Format | |
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Tutik Wresdiawati.pdf | e-Journal | 123.87 kB | Adobe PDF | View/Open |
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