Potensi Anti-Hiperkolesterolemia ekstrak cassia vera (Cinnamomum burmanni Nees ex Blume)

Abstract

There has been limited report on the phytochemical content of cassia Vera bark extract, and its potency as antihyperchdesterolemic in rabbit is nd known yet The d,#x-tties of this reseamh was to determine the phytochemical confent and patency of anti-hypercholesterdemic of cassia Vera bak extrad using rabbit as the animal model. The research was devided into three stages, namely: (I) p m ' n g cassia vem extredr'on wiih ethanol 96%; (2) analyzing phytocMica1 contents of cassia Vera bark extrad; (3) in vivo expenlnent, where twenty N&v Zealand mite rabbits aged 5 months m used. Experimental rabbits were divided into 5 groups. The mbbits nee fed with athemgenic cholesterd (0.1%) as positive confd, RBll standard feed as negative control, w cassia Vera extracts (100 tng'kdday w 200 mglkgday) of fenofibral(75 mglday) togefher with the atherogenic feed for 12 m k s . Levels of s e w tdal cholesterd, t-, HHDLchokfed and LDLchalesterol were determined at 0, 4, 8, and 12 week. At the end of the experiment formafion d fat& k'ver wm &wed. The lasuBs showed that the ethand extract of cassia Vera bark contains tdal phenol (62.25%), flm, frifqmid, saponin and a l k M On the &her hand, cask vcm bark extract was able to decrease tdal serum cholesterd ftwn 443.3 @dl to 739.1 mg/di, UX choiesterd h 286.5 ms/d to 95.8 mgdl and trigljwide from 722.2 @dl to 61.2 rng/dl. Meanruhile, it i t e d HDL serum c M e r o l h m 29.1 W d I to 50.0 ms/dI in mbb~?. It was also shown that the extrad was able to decrease the everage fat glob& on liver significady from 27.47 globule to 3.59 globule per field view. Cassia vera bark extract with phytrxhmicd content was found to be potential as anti-hypercholesterdemic and also in preventing fatty liver formatonr in mbbt