Perbandingan Sekuens Konsensus Gen Hemaglutinin Virus Avian Influenza Subtipe H5N1 Asal Unggas di Indonesia dengan Subtipe H5N2 dan H5N9

Abstract

Consensus sequence of hemagglutinin (HA) gene of avian influenza viruses of H5N1 subtype isolated from fowl in Indonesia -hereafter named as H5N1-Indonesia -is compared with that of H5N2 and H5N9 viruses. Sequence information were downloaded from the public database GeneBank. The genetic distances and nucleotide as well as its deduced amino-acid sequence alignment were analysed. At nucleotide level, genetic distances of HA between H5NlJndonesia to H5N2 and H5N9 are 16.2% and 9.6%, respectively. At amino-acid level, the distances are 9.7% and 6.8%. The genetic distances of HA1 fragments are 19.0% (H5N1-Indonesia - H5N2) and 10.9% (H5N1-Indonesia - H5N9). At amino-acid, level the genetic distances of HA1 are 13.1% (H5Nl-Indonesia-H5N2) and 8.8% (H5N1-Indonesia - H5N9). All three subtypes have different glycosilation motive and variation of amino-acid sequence of four antigenic sites. The consequence of those facts is discussed.